Vol. 7, Issue 1, Part A (2025)

Introduction: Kidney disease during human immunodeficiency virus (HIV) infection is frequent and often silent. Objective: To study the factors associated with kidney disease (acute and chronic) in PLHIV at the CHD-Zou/Collines (Benin) in 2024.
Methods: This was a cross-sectional study, conducted from 1 August to 30 November 2024, involving all PLHIV followed up in the medical department of the Zou/Collines departmental hospital (CHD) who had a creatinine level at least three months old, a recent CD4 count and viral load less than three months old, were able to answer the questions and had given informed consent. Renal damage was studied according to acute and chronic mode (KDIGO criteria). 
Sampling was exhaustive. Associated factors were identified at a significance level of p<0.05. 
Results: A total of 143 PLHIV were included and 30 had renal involvement, i.e. a prevalence of 20.98%. The mean age was 44.74 ± 13.08 years, with a sex ratio of 0.43. The kidney diseases were vascular nephropathy syndrome (5.59%), acute interstitial nephropathy (4.20%), acute tubular nephropathy (5.59%), glomerular nephropathy (3.50%) and chronic tubulointerstitial nephropathy (2.09%). Acute renal damage and chronic kidney disease stages 3-5 were found in 6.29% and 9.99% respectively, and in multivariate analysis, the occurrence of renal damage was associated with a CD4 count < 200 cells/mm3 (p-value = 0.001).
Conclusion: The frequency of kidney damage in people living with HIV is high. Enhanced immunity would facilitate nephroprotection.