Vol. 3, Issue 1, Part A (2021)

Post infectious glomerulonephritis, an immunologic response of the kidney to infection, commonly triggered by streptococci. Besides this common infection other organism may incite the pathophysiology. However, clinicopathological features of infection related glomerulonephritis in adults are less elucidated particularly in our perspective. Objective: The objective of the study was to determine the clinicopathological features of infection related glomerulonephritis patients admitted in a tertiary care hospital. Methods: This prospective study was conducted at the department of Nephrology in Dhaka Medical College and Hospital, from January 2018 to July 2019 following ethical approval. Total 71 infection related glomerulonephritis cases were included in this study after renal biopsy. Informed written consent was ensured for all participants. Collected data were focused on demographic profile, site of infection and relevant investigations. Data collection was carried out by the investigator herself. Data analysis were done SPSS 22 windows 7 version. Results: Mean age of all study subjects was 41.61±15.35 SD (years) with slightly male predominance (M: F-1.27:1). Skin infection and URTI were the two most common site of infection found among the patients (46.50%). Unknown site of infection was found in a large portion of the population (36.60%). Nephritic presentation was the most common presentation. Oedema was the most prominent features of the patient (90.1%) but oliguria and hypertension were also present in larger amount. Forty one patients had endocapillary proliferation, twenty three patients had endocapillary & mesangial proliferation and seven had mesangial proliferation. On IF, all staining was seen with C3 with or without presence of staining of other immunoglobulins. Conclusion: Endocapillary, endocapillary & mesangial and mesangial proliferation were the three histological pattern observed in infection related glomerulonephritis in our perspective which most commonly present with oedema and oliguria